Once again the folks from Tutsplus (formely WP Tuts) deliver. Ahmad Awais did a little series for them on setting up and using the awesome SEO plugin from Yoast:
We’ll have a course on Treehouse soon that covers all this, plus hopefully a little guest appearance from Yoast himself, but for the meantime, I encourage you to check out this resource if you ever need a hand.
I think that a lot of people who install this plugin don’t actually take advantage of the On Page SEO options, so I would especially suggest you read the last article if you’re familiar with setting up the actual plugin.